Comparisons of anti-human immunodeficiency virus activities, cellular transport, and plasma and intracellular pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-azido-3'-deoxythymidine.

3'-Fluoro-3'-deoxythymidine (FLT), a candidate anti-AIDS compound in clinical trials, showed anti-human immunodeficiency virus type 1 (HIV-1) potency (50% effective concentration, 0.0052 microM) slightly better than or equal to that of 3'-azido-3'-deoxythymidine (AZT) in MT4 cells and was threefold...

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Publicado en:	Antimicrob Agents Chemother
Autores principales:	Kong, X B, Zhu, Q Y, Vidal, P M, Watanabe, K A, Polsky, B, Armstrong, D, Ostrander, M, Lang, S A, Muchmore, E, Chou, T C
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1992
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC189428/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1503443/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.36.4.808
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