Maternal germ-line transmission of mutant mtDNAs from embryonic stem cell-derived chimeric mice
We report a method for introducing mtDNA mutations into the mouse female germ line by means of embryonic stem (ES) cell cybrids. Mitochondria were recovered from the brain of a NZB mouse by fusion of synaptosomes to a mtDNA-deficient (ρ°) cell line. These cybrids were enucleated and the cytoplasts w...
Gorde:
| Argitaratua izan da: | Proc Natl Acad Sci U S A |
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| Egile Nagusiak: | , , , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
National Academy of Sciences
2000
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18941/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11106380/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.250491597 |
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