Mapping of mutations contributing to the temperature sensitivity of the Sabin 1 vaccine strain of poliovirus.

The temperature-sensitive and attenuated phenotypes of the Sabin type 1 vaccine strain of poliovirus result from numerous point mutations which occurred in the virulent Mahoney virus parent. One of these mutations is located in a 3D polymerase (3Dpol) codon (U-6203-->C, Tyr-73-->His) and is involved...

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Veröffentlicht in:	J Virol
Hauptverfasser:	Georgescu, M M, Tardy-Panit, M, Guillot, S, Crainic, R, Delpeyroux, F
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1995
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC189363/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7636970/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.69.9.5278-5286.1995
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