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Mechanism of interferon action: characterization of the intermolecular autophosphorylation of PKR, the interferon-inducible, RNA-dependent protein kinase.

The interferon-inducible, RNA-dependent protein kinase (PKR) is activated by autophosphorylation, a process mediated by double-stranded RNA. A catalytically deficient, histidine-tagged mutant PKR protein [His-PKR(K296R)] was used as the substrate for characterization of the intermolecular phosphoryl...

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Detalhes bibliográficos
Publicado no:J Virol
Principais autores: Thomis, D C, Samuel, C E
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1995
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC189345/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7541849/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.69.8.5195-5198.1995
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