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Cell stress modulates the function of splicing regulatory protein RBM4 in translation control

RNA-binding motif protein 4 (RBM4) plays a regulatory role in alternative splicing of precursor mRNA. We show here that cell stress such as arsenite exposure induces phosphorylation of RBM4 at serine 309 and also drives its cytoplasmic accumulation and targeting to stress granule via the MKK(3/6)-p3...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Lin, Jung-Chun, Hsu, Min, Tarn, Woan-Yuh
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1893002/
https://ncbi.nlm.nih.gov/pubmed/17284590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611015104
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