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Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5

Skeletal muscle differentiation is controlled by interactions between myocyte enhancer factor-2 (MEF2) and myogenic basic helix—loop–helix transcription factors. Association of MEF2 with histone deacetylases (HDAC) -4 and -5 results in repression of MEF2 target genes and inhibition of myogenesis. Ca...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Principais autores: McKinsey, Timothy A., Zhang, Chun Li, Olson, Eric N.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2000
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18930/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11114197/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.260501497
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