Nitric oxide negatively regulates c-Jun N-terminal kinase/stress-activated protein kinase by means of S-nitrosylation

NO, produced from l-arginine in a reaction catalyzed by NO synthase, is an endogenous free radical with multiple functions in mammalian cells. Here, we demonstrate that endogenously produced NO can suppress c-Jun N-terminal kinase (JNK) activation in intact cells. Treatment of BV-2 murine microglial...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Park, Hee-Sae, Huh, Sung-Ho, Kim, Mi-Sung, Lee, Soo Hwan, Choi, Eui-Ju
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 2000
Fag:	Biological Sciences
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18927/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11121042/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.26.14382
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