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Nitric oxide negatively regulates c-Jun N-terminal kinase/stress-activated protein kinase by means of S-nitrosylation

NO, produced from l-arginine in a reaction catalyzed by NO synthase, is an endogenous free radical with multiple functions in mammalian cells. Here, we demonstrate that endogenously produced NO can suppress c-Jun N-terminal kinase (JNK) activation in intact cells. Treatment of BV-2 murine microglial...

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Detalhes bibliográficos
Main Authors: Park, Hee-Sae, Huh, Sung-Ho, Kim, Mi-Sung, Lee, Soo Hwan, Choi, Eui-Ju
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC18927/
https://ncbi.nlm.nih.gov/pubmed/11121042
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