Chemical Knockout of Pantothenate Kinase Reveals the Metabolic and Genetic Program Responsible for Hepatic Coenzyme A Homeostasis

Coenzyme A (CoA) is the major acyl group carrier in intermediary metabolism. Hopantenate (HoPan), a competitive inhibitor of the pantothenate kinases, was used to chemically antagonize CoA biosynthesis. HoPan dramatically reduced liver CoA levels and the mice developed severe hypoglycemia. Insulin a...

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Autori principali: Zhang, Yong-Mei, Chohnan, Shigeru, Virga, Kristopher G., Stevens, Robert D., Ilkayeva, Olga R., Wenner, Brett R., Bain, James R., Newgard, Christopher B., Lee, Richard E., Rock, Charles O., Jackowski, Suzanne
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1892532/
https://ncbi.nlm.nih.gov/pubmed/17379144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2007.01.013
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