Spontaneous Aberrant Crypt Foci in Apc1638N Mice with a Mutant Apc Allele

The Apc1638N/+ mouse has a chain-terminating mutation in one allele of the adenomatous polyposis coli (Apc) gene that is similar to most mutations observed in the human familial adenomatous polyposis syndrome. Aberrant crypt foci (ACF), the earliest identified neoplastic lesions in the colon, are mo...

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Bibliographic Details
Main Authors: Pretlow, Theresa P., Edelmann, Winfried, Kucherlapati, Raju, Pretlow, Thomas G., Augenlicht, Leonard H.
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2003
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1892417/
https://ncbi.nlm.nih.gov/pubmed/14578176
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