In vitro activity of pirodavir (R 77975), a substituted phenoxy-pyridazinamine with broad-spectrum antipicornaviral activity.

Pirodavir (R 77975) is the prototype of a novel class of broad-spectrum antipicornavirus compounds. Although its predecessor, R 61837, a substituted phenyl-pyridazinamine, was effective in inhibiting 80% of 100 serotypes tested (EC80) at concentrations above 32 micrograms/ml, pirodavir inhibits the...

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izdano v:	Antimicrob Agents Chemother
Principais autores:	Andries, K, Dewindt, B, Snoeks, J, Willebrords, R, van Eemeren, K, Stokbroekx, R, Janssen, P A
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology (ASM) 1992
Teme:	Research Article
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC189235/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1317142/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.36.1.100
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