A central region in the hepatitis C virus NS4A protein allows formation of an active NS3-NS4A serine proteinase complex in vivo and in vitro.

A virus-encoded serine proteinase mediates four site-specific cleavages in the hepatitis C virus polyprotein. In addition to the catalytic domain, which is located in the N-terminal one-third of nonstructural protein NS3, the 54-residue NS4A protein is required for cleavage at some but not all sites...

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Veröffentlicht in:	J Virol
Hauptverfasser:	Lin, C, Thomson, J A, Rice, C M
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1995
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC189178/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7769699/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.69.7.4373-4380.1995
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