A central region in the hepatitis C virus NS4A protein allows formation of an active NS3-NS4A serine proteinase complex in vivo and in vitro.

A virus-encoded serine proteinase mediates four site-specific cleavages in the hepatitis C virus polyprotein. In addition to the catalytic domain, which is located in the N-terminal one-third of nonstructural protein NS3, the 54-residue NS4A protein is required for cleavage at some but not all sites...

Full description

Saved in:
Bibliographic Details
Main Authors: Lin, C, Thomson, J A, Rice, C M
Format: Artigo
Language:Inglês
Published: 1995
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC189178/
https://ncbi.nlm.nih.gov/pubmed/7769699
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items