Frequency of germline hereditary non-polyposis colorectal cancer gene mutations in patients with multiple or early onset colorectal adenomas

Background—The hereditary non-polyposis colorectal cancer (HNPCC) syndrome is caused by germline mutations in mismatch repair genes and predisposes individuals to cancers of the colon and other specific sites. On theoretical grounds, it is expected that patients with HNPCC also develop more colorect...

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Detalles Bibliográficos
Main Authors: Beck, N, Tomlinson, I, Homfray, T, Frayling, I, Hodgson, S, Bodmer, W
Formato: Artigo
Idioma:Inglês
Publicado: 1997
Assuntos:
Colorectal Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1891471/
https://ncbi.nlm.nih.gov/pubmed/9301504
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