Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion

The RhoA-effector Dia1 controls actin-dependent processes such as cytokinesis, SRF transcriptional activity, and cell motility. Dia1 polymerizes actin through its formin homology (FH) 2 domain. Here we show that Dia1 acts upstream of RhoA independently of its effects on actin assembly. Dia1 binds to...

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Detalhes bibliográficos
Main Authors: Kitzing, Thomas M., Sahadevan, Arul S., Brandt, Dominique T., Knieling, Helga, Hannemann, Sebastian, Fackler, Oliver T., Großhans, Jörg, Grosse, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2007
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1891425/
https://ncbi.nlm.nih.gov/pubmed/17575049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.424807
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