Butyrate mediates decrease of histone acetylation centered on transcription start sites and down-regulation of associated genes

Butyrate is a histone deacetylase inhibitor (HDACi) with anti-neoplastic properties, which theoretically reactivates epigenetically silenced genes by increasing global histone acetylation. However, recent studies indicate that a similar number or even more genes are down-regulated than up-regulated...

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Autors principals: Rada-Iglesias, Alvaro, Enroth, Stefan, Ameur, Adam, Koch, Christoph M., Clelland, Gayle K., Respuela-Alonso, Patricia, Wilcox, Sarah, Dovey, Oliver M., Ellis, Peter D., Langford, Cordelia F., Dunham, Ian, Komorowski, Jan, Wadelius, Claes
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2007
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1891332/
https://ncbi.nlm.nih.gov/pubmed/17567991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.5540007
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