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Butyrate mediates decrease of histone acetylation centered on transcription start sites and down-regulation of associated genes
Butyrate is a histone deacetylase inhibitor (HDACi) with anti-neoplastic properties, which theoretically reactivates epigenetically silenced genes by increasing global histone acetylation. However, recent studies indicate that a similar number or even more genes are down-regulated than up-regulated...
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| 主要な著者: | , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Cold Spring Harbor Laboratory Press
2007
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1891332/ https://ncbi.nlm.nih.gov/pubmed/17567991 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.5540007 |
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