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Explaining the high mutation rates of cancer cells to drug and multidrug resistance by chromosome reassortments that are catalyzed by aneuploidy
The mutation rates of cancer cells to drug and multidrug resistance are paradoxically high, i.e., 10(−3) to 10(−6), compared with those altering phenotypes of recessive genes in normal diploid cells of about 10(−12). Here the hypothesis was investigated that these mutations are due to chromosome rea...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC18912/ https://ncbi.nlm.nih.gov/pubmed/11121035 |
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