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Perforin gene mutations in patients with acquired aplastic anemia
Perforin is a cytolytic protein expressed mainly in activated cytotoxic lymphocytes and natural killer cells. Inherited perforin mutations account for 20% to 40% of familial hemophagocytic lymphohistiocytosis, a fatal disease of early childhood characterized by the absence of functional perforin. Ap...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1890825/ https://ncbi.nlm.nih.gov/pubmed/17311987 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-12-063495 |
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