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What is the role of non-native intermediates of β-lactoglobulin in protein folding?

The mechanism of α→β transition in folding of β-lactoglobulin is discussed based on free energy landscape analysis of a long lattice model. It is found that helical propensity of β-lactoglobulin is driven by conformational entropy and is intrinsically coded in its native structure. We propose a view...

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Autori principali: Chikenji, George, Kikuchi, Macoto
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2000
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC18908/
https://ncbi.nlm.nih.gov/pubmed/11121033
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