Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice

Parkinson's disease (PD) is characterized by the selective vulnerability of the nigrostriatal dopaminergic circuit. Recently, loss-of-function mutations in the PTEN-induced kinase 1 (PINK1) gene have been linked to early-onset PD. How PINK1 deficiency causes dopaminergic dysfunction and degener...

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Autori principali: Kitada, Tohru, Pisani, Antonio, Porter, Douglas R., Yamaguchi, Hiroo, Tscherter, Anne, Martella, Giuseppina, Bonsi, Paola, Zhang, Chen, Pothos, Emmanuel N., Shen, Jie
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2007
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1890561/
https://ncbi.nlm.nih.gov/pubmed/17563363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702717104
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