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A connecting hinge represses the activity of endothelial nitric oxide synthase

In mammals, endothelial nitric oxide synthase (eNOS) has the weakest activity, being one-tenth and one-sixth as active as the inducible NOS (iNOS) and the neuronal NOS (nNOS), respectively. The basis for this weak activity is unclear. We hypothesized that a hinge element that connects the FMN module...

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Detalhes bibliográficos
Main Authors: Haque, Mohammad Mahfuzul, Panda, Koustubh, Tejero, Jesús, Aulak, Kulwant S., Fadlalla, Mohammed Adam, Mustovich, Anthony T., Stuehr, Dennis J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1890481/
https://ncbi.nlm.nih.gov/pubmed/17517617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700332104
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