The covalently closed duplex form of the hepadnavirus genome exists in situ as a heterogeneous population of viral minichromosomes.

Replication of hepadnaviruses requires a persistent population of covalently closed circular (CCC) DNA molecules in the nucleus of the infected cell. It is widely accepted that the vital role of this molecule is to be the sole DNA template for the synthesis by RNA polymerase II of all viral transcri...

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Detalles Bibliográficos

Publicado en:	J Virol
Principais autores:	Newbold, J E, Xin, H, Tencza, M, Sherman, G, Dean, J, Bowden, S, Locarnini, S
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology (ASM) 1995
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC189047/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7745682/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.69.6.3350-3357.1995
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