The covalently closed duplex form of the hepadnavirus genome exists in situ as a heterogeneous population of viral minichromosomes.

Replication of hepadnaviruses requires a persistent population of covalently closed circular (CCC) DNA molecules in the nucleus of the infected cell. It is widely accepted that the vital role of this molecule is to be the sole DNA template for the synthesis by RNA polymerase II of all viral transcri...

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Vydáno v:	J Virol
Hlavní autoři:	Newbold, J E, Xin, H, Tencza, M, Sherman, G, Dean, J, Bowden, S, Locarnini, S
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1995
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC189047/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7745682/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.69.6.3350-3357.1995
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