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Isoform-dependent interaction of voltage-gated sodium channels with protons
Protons are potent physiological modifiers of voltage-gated Na(+) channels, shifting the voltage range of channel gating and reducing current magnitude (pK(a) ∼6). We recently showed that proton block of the skeletal muscle isoform (Na(v)1.4) resulted from protonation of the four superficial carboxy...
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| Asıl Yazarlar: | , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Blackwell Science Inc
2006
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1890365/ https://ncbi.nlm.nih.gov/pubmed/16873405 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.115659 |
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