Characterization of a human immunodeficiency virus type 1 variant with reduced sensitivity to an aminodiol protease inhibitor.

Development of viral resistance to the aminodiol human immunodeficiency virus (HIV) protease inhibitor BMS 186,318 was studied by serial passage of HIV type 1 RF in MT-2 cells in the presence of increasing concentrations of compound. After 11 passages, an HIV variant that showed a 15-fold increase i...

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Pubblicato in:	J Virol
Autori principali:	Patick, A K, Rose, R, Greytok, J, Bechtold, C M, Hermsmeier, M A, Chen, P T, Barrish, J C, Zahler, R, Colonno, R J, Lin, P F
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1995
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC188882/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7884862/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.69.4.2148-2152.1995
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