An etoposide-induced block in vaccinia virus telomere resolution is dependent on the virus-encoded DNA ligase.

Etoposide, an inhibitor of the breakage-reunion reaction associated with cellular type II DNA topoisomerases, was shown to inhibit plaque formation of vaccinia virus. This drug had a major effect on the segregation of newly replicated DNA concatemers. Gene expression and the initiation and elongatio...

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Bibliographic Details
Main Authors: DeLange, A M, Carpenter, M S, Choy, J, Newsway, V E
Format: Artigo
Language:Inglês
Published: 1995
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC188874/
https://ncbi.nlm.nih.gov/pubmed/7884854
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