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Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain
Proinflammatory agents trypsin and mast cell tryptase cleave and activate PAR2, which is expressed on sensory nerves to cause neurogenic inflammation. Transient receptor potential A1 (TRPA1) is an excitatory ion channel on primary sensory nerves of pain pathway. Here, we show that a functional inter...
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| Hoofdauteurs: | , , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society for Clinical Investigation
2007
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1888570/ https://ncbi.nlm.nih.gov/pubmed/17571167 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30951 |
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