Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain

Proinflammatory agents trypsin and mast cell tryptase cleave and activate PAR2, which is expressed on sensory nerves to cause neurogenic inflammation. Transient receptor potential A1 (TRPA1) is an excitatory ion channel on primary sensory nerves of pain pathway. Here, we show that a functional inter...

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Autores principales: Dai, Yi, Wang, Shenglan, Tominaga, Makoto, Yamamoto, Satoshi, Fukuoka, Tetsuo, Higashi, Tomohiro, Kobayashi, Kimiko, Obata, Koichi, Yamanaka, Hiroki, Noguchi, Koichi
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2007
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1888570/
https://ncbi.nlm.nih.gov/pubmed/17571167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30951
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