Human immunodeficiency virus type 1 Nef protein inhibits activation pathways in peripheral blood mononuclear cells and T-cell lines.

Human immunodeficiency virus type 1 (HIV-1) Nef protein causes the loss of cell surface CD4 and interleukin-2 (IL-2) receptor (Tac) from peripheral blood mononuclear cells (PBMC) and CD4+ T-cell lines. As both CD4 and the IL-2 receptor play crucial roles in antigen-driven helper T-cell signalling an...

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Bibliographic Details
Main Authors: Greenway, A, Azad, A, McPhee, D
Format: Artigo
Language:Inglês
Published: 1995
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC188795/
https://ncbi.nlm.nih.gov/pubmed/7853525
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