Liposomal vaccines with conformation-specific amyloid peptide antigens define immune response and efficacy in APP transgenic mice

We investigated the therapeutic effects of two different versions of Aβ(1–15 (16)) liposome-based vaccines. Inoculation of APP-V717IxPS-1 (APPxPS-1) double-transgenic mice with tetra-palmitoylated amyloid 1–15 peptide (palmAβ(1–15)), or with amyloid 1–16 peptide (PEG-Aβ(1–16)) linked to a polyethyle...

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Detalhes bibliográficos
Main Authors: Muhs, Andreas, Hickman, David T., Pihlgren, Maria, Chuard, Nathalie, Giriens, Valérie, Meerschman, Carine, van der Auwera, Ingrid, van Leuven, Fred, Sugawara, Masae, Weingertner, Marie-Catherine, Bechinger, Burkhard, Greferath, Ruth, Kolonko, Nadine, Nagel-Steger, Luitgard, Riesner, Detlev, Brady, Roscoe O., Pfeifer, Andrea, Nicolau, Claude
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1887581/
https://ncbi.nlm.nih.gov/pubmed/17517595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0703137104
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