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Mutagenesis of the yellow fever virus NS2B/3 cleavage site: determinants of cleavage site specificity and effects on polyprotein processing and viral replication.

The determinants of cleavage site specificity of the yellow fever virus (YF) NS3 proteinase for its 2B/3 cleavage site have been studied by using site-directed mutagenesis. Mutations at residues within the GARR decreases S sequence were tested for effects on cis cleavage of an NS2B-3(181) polyprotei...

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Detalhes bibliográficos
Publicado no:J Virol
Principais autores: Chambers, T J, Nestorowicz, A, Rice, C M
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1995
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC188755/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7853494/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.69.3.1600-1605.1995
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