Cleavage at a novel site in the NS4A region by the yellow fever virus NS2B-3 proteinase is a prerequisite for processing at the downstream 4A/4B signalase site.

Flavivirus proteins are produced by co- and posttranslational proteolytic processing of a large polyprotein by both host- and virus-encoded proteinases. The viral serine proteinase, which consists of NS2B and NS3, is responsible for cleavage of at least four dibasic sites (2A/2B, 2B/3, 3/4A, and 4B/...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Lin, C, Amberg, S M, Chambers, T J, Rice, C M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240389/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8445732/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.67.4.2327-2335.1993
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