Simian immunodeficiency virus SIVmac chimeric virus whose env gene was derived from SIV-encephalitic brain is macrophage-tropic but not neurovirulent.

We inoculated four rhesus macaques with molecularly cloned simian immunodeficiency virus SIVmac239/17E env, a chimeric virus whose env gene was derived from the brain of an SIV-encephalitic macaque. Blood and lymphoid tissues had high frequencies of infected cells. The virus was neuroinvasive, but p...

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Bibliographic Details
Main Authors: Joag, S V, Stephens, E B, Galbreath, D, Zhu, G W, Li, Z, Foresman, L, Zhao, L J, Pinson, D M, Narayan, O
Format: Artigo
Language:Inglês
Published: 1995
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC188722/
https://ncbi.nlm.nih.gov/pubmed/7815523
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