Targeting of the rasT24 oncogene to the proximal convoluted tubules in transgenic mice results in hyperplasia and polycystic kidneys.

Five families of transgenic mice were derived from one-cell-stage embryos injected with gamma GT-rasT24, a fusion gene consisting of the gamma-glutamyl transpeptidase (gamma GT) 5' flanking region containing promoter I linked to a mutated (codon 12) human H-ras oncogene. The transgene was expre...

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Autori principali: Schaffner, D. L., Barrios, R., Massey, C., Bañez, E. I., Ou, C. N., Rajagopalan, S., Aguilar-Cordova, E., Lebovitz, R. M., Overbeek, P. A., Lieberman, M. W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1993
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1886875/
https://ncbi.nlm.nih.gov/pubmed/8097368
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