Expression of the rasT24 oncogene in the ciliary body pigment epithelium and retinal pigment epithelium results in hyperplasia, adenoma, and adenocarcinoma.

We examined eye lesions in five lines of transgenic mice carrying the human rasT24 oncogene driven by the type I gamma glutamyl transferase (gamma GT) promoter. In three lines, hyperplasia developed as early as 11.5 days postconception in the outer neuroectodermal layer, which gives rise to ciliary...

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Bibliographic Details
Main Authors: Chévez-Barrios, P., Schaffner, D. L., Barrios, R., Overbeek, P. A., Lebovitz, R. M., Lieberman, M. W.
Format: Artigo
Language:Inglês
Published: 1993
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1886968/
https://ncbi.nlm.nih.gov/pubmed/8100399
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