Abnormal Hair Development and Apparent Follicular Transformation to Mammary Gland in the Absence of Hedgehog Signaling

We show that removing the Shh signal tranducer Smoothened from skin epithelium secondarily results in excess Shh levels in the mesenchyme. Moreover, the phenotypes we observe reflect decreased epithelial Shh signaling, yet increased mesenchymal Shh signaling. For example, the latter contributes to e...

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Autores principales: Gritli-Linde, Amel, Hallberg, Kristina, Harfe, Brian D., Reyahi, Azadeh, Kannius-Janson, Marie, Nilsson, Jeanette, Cobourne, Martyn T., Sharpe, Paul T., McMahon, Andrew P., Linde, Anders
Formato: Artigo
Lenguaje:Inglês
Publicado: Cell Press 2007
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885956/
https://ncbi.nlm.nih.gov/pubmed/17199044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2006.12.006
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