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The Cell Cycle Cdc25A Tyrosine Phosphatase Is Activated in Degenerating Postmitotic Neurons in Alzheimer’s Disease

The Cdc25 phosphatases play key roles in cell-cycle progression by activating cyclin-dependent kinases. The latter are absent from neurons that are terminally differentiated in adult brain. However, accumulation of mitotic phosphoepitopes, and re-expression and activation of the M phase regulator, C...

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Autors principals: Ding, Xiao-Ling, Husseman, Jacob, Tomashevski, Andrei, Nochlin, David, Jin, Lee-Way, Vincent, Inez
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2000
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885767/
https://ncbi.nlm.nih.gov/pubmed/11106571
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