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A tractable method for simultaneous modifications to the head and tail of bacteriophage lambda and its application to enhancing phage-mediated gene delivery

There is considerable interest in the use of bacteriophage vectors for mammalian cell gene transfer applications, due to their stability, excellent safety profile and inexpensive mass production. However, to date, phage vectors have been plagued by mediocre performance as gene transfer agents. This...

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Bibliographic Details
Main Authors: Zanghi, Christine N., Sapinoro, Ramil, Bradel-Tretheway, Birgit, Dewhurst, Stephen
Format: Artigo
Language:Inglês
Published: Oxford University Press 2007
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885665/
https://ncbi.nlm.nih.gov/pubmed/17392341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm146
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