Topoisomerase II, scaffold component, promotes chromatin compaction in vitro in a linker-histone H1-dependent manner

TopoisomeraseII (Topo II) is a major component of chromosomal scaffolds and essential for mitotic chromosome condensation, but the mechanism of this action remains unknown. Here, we used an in vitro chromatin reconstitution system in combination with atomic force and fluorescence microscopic analyse...

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Hlavní autoři: Hizume, Kohji, Araki, Sumiko, Yoshikawa, Kenichi, Takeyasu, Kunio
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2007
Témata:
Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885653/
https://ncbi.nlm.nih.gov/pubmed/17430970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm116
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