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Protective Effect of Vitamin C against Double-Strand Breaks in Reconstituted Chromatin Visualized by Single-Molecule Observation

Direct attack to genomic DNA by reactive oxygen species causes various types of lesions, including base modifications and strand breaks. The most significant lesion is considered to be an unrepaired double-strand break that can lead to fatal cell damage. We directly observed double-strand breaks of...

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Main Authors: Yoshikawa, Yuko, Hizume, Kohji, Oda, Yoshiko, Takeyasu, Kunio, Araki, Sumiko, Yoshikawa, Kenichi
Format: Artigo
Jezik:Inglês
Izdano: Biophysical Society 2006
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1367124/
https://ncbi.nlm.nih.gov/pubmed/16284271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.069963
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