Protective Effect of Vitamin C against Double-Strand Breaks in Reconstituted Chromatin Visualized by Single-Molecule Observation

Direct attack to genomic DNA by reactive oxygen species causes various types of lesions, including base modifications and strand breaks. The most significant lesion is considered to be an unrepaired double-strand break that can lead to fatal cell damage. We directly observed double-strand breaks of...

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Bibliografiske detaljer
Main Authors: Yoshikawa, Yuko, Hizume, Kohji, Oda, Yoshiko, Takeyasu, Kunio, Araki, Sumiko, Yoshikawa, Kenichi
Format: Artigo
Sprog:Inglês
Udgivet: Biophysical Society 2006
Fag:
Nucleic Acids
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1367124/
https://ncbi.nlm.nih.gov/pubmed/16284271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.069963
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