Lack of endothelial cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure

We explored the physiologic role of endothelial cell apoptosis during development by generating mouse embryos lacking the inhibitor of apoptosis protein (IAP) survivin in endothelium. This was accomplished by intercrossing survivin(lox/lox) mice with mice expressing cre recombinase under the control...

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Bibliographic Details
Main Authors: Zwerts, Femke, Lupu, Florea, De Vriese, Astrid, Pollefeyt, Saskia, Moons, Lieve, Altura, Rachel A., Jiang, Yuying, Maxwell, Patrick H., Hill, Peter, Oh, Hideyasu, Rieker, Claus, Collen, Désiré, Conway, Simon J., Conway, Edward M.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2007
Subjects:
Hemostasis, Thrombosis, and Vascular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885533/
https://ncbi.nlm.nih.gov/pubmed/17299096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-06-028068
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