Lack of endothelial cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure

We explored the physiologic role of endothelial cell apoptosis during development by generating mouse embryos lacking the inhibitor of apoptosis protein (IAP) survivin in endothelium. This was accomplished by intercrossing survivin(lox/lox) mice with mice expressing cre recombinase under the control...

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Hlavní autoři: Zwerts, Femke, Lupu, Florea, De Vriese, Astrid, Pollefeyt, Saskia, Moons, Lieve, Altura, Rachel A., Jiang, Yuying, Maxwell, Patrick H., Hill, Peter, Oh, Hideyasu, Rieker, Claus, Collen, Désiré, Conway, Simon J., Conway, Edward M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2007
Témata:
Hemostasis, Thrombosis, and Vascular Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885533/
https://ncbi.nlm.nih.gov/pubmed/17299096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-06-028068
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