ELUCIDATION OF HUMAN CHOLINE KINASE CRYSTAL STRUCTURES IN COMPLEX WITH THE PRODUCTS ADP OR PHOSPHOCHOLINE

Choline kinase, responsible for the phosphorylation of choline to phosphocholine as the first step of the CDP-choline pathway for the biosynthesis of phosphatidylcholine, has been recognized as a new target for anticancer therapy. Crystal structures of human choline kinase in its apo, ADP- and phosp...

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Main Authors: Malito, Enrico, Sekulic, Nikolina, Too, Wei Cun See, Konrad, Manfred, Lavie, Arnon
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2006
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885479/
https://ncbi.nlm.nih.gov/pubmed/17007874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2006.08.084
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