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Synthesis and Evaluation of Isosteres of N-Methyl Indolo[3, 2-b]-quinoline (Cryptolepine) as New Antiinfective Agents.
Isosteres of cryptolepine (1) were synthesized and evaluated for their antiinfective activities. Overall, the sulfur isostere, 5-methyl benzothieno[3,2-b]quinoline (5b) was equipotent to 1 and has shown no cytotoxicity at 23.8 μg/ml. Compound 5b was also found to have a broad spectrum of activity. B...
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| Main Authors: | , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2006
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1885469/ https://ncbi.nlm.nih.gov/pubmed/17134906 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2006.10.062 |
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