Solid Phase-Assisted Synthesis and Screening of a Small Library of N-(4-Hydroxyphenyl)retinamide (4-HPR) Analogs

Using solid phase-assisted synthesis and purification, a 49 member library of analogs of the mammary tumor chemopreventive retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) has been prepared. After prescreening for growth inhibitory activity in human mammary tumor cells (MCF-7) in culture, most of thos...

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Main Authors: Mershon, Serena M., Anding, Allyson L., Chapman, Jason S., Clagett-Dame, Margaret, Stonerock, Laura A., Curley, Robert W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885232/
https://ncbi.nlm.nih.gov/pubmed/17112722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2006.10.05
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