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Selective Cleavage of Isoaspartyl Peptide Bonds by Hydroxylamine after Methyltransferase Priming
Formation of atypical isoaspartyl (isoAsp) sites in peptides and proteins via the deamidation-linked isomerization of asparaginyl-Xaa bonds or direct isomerization of aspartyl-Xaa bonds is a major contributor to spontaneous protein damage under mild conditions. This nonenzymatic reaction reroutes th...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2007
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1885207/ https://ncbi.nlm.nih.gov/pubmed/17376395 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2007.02.013 |
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