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Manganese Superoxide Dismutase Protects against 6-Hydroxydopamine Injury in Mouse Brains

Dopaminergic neurons of the substantia nigra are susceptible to toxin-based insults. Intrastriatal injection of 6-hydroxydopamine results in selective toxicity to these neurons. A mechanistic role for reactive oxygen species is supported by observations that antioxidants confer protection from 6-hyd...

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Hlavní autoři: Callio, Jason, Oury, Tim D., Chu, Charleen T.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2005
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885201/
https://ncbi.nlm.nih.gov/pubmed/15755737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M413224200
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