A case study of acenocoumarol sensitivity and genotype-phenotype discordancy explained by combinations of polymorphisms in VKORC1 and CYP2C9

AIMS: To determine the cause of a genotype-phenotype discordancy for acenocoumarol sensitivity. METHODS: A patient, highly sensitive to acenocoumarol, and previously determined to carry only a single CYP2C9 *3 allele, was genotyped for additional functionally defective alleles in the CYP2C9 and VKOR...

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Dettagli Bibliografici
Autori principali: Rettie, Allan E, Farin, Frederico M, Beri, Nitasha G, Srinouanprachanh, Sengkeo L, Rieder, Mark J, Thijssen, Henk H
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2006
Soggetti:
Short Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885169/
https://ncbi.nlm.nih.gov/pubmed/16869821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2006.02688.x
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