Development of a dosage strategy in patients receiving enoxaparin by continuous intravenous infusion using modelling and simulation

AIM: To develop an appropriate dosing strategy for continuous intravenous infusions (CII) of enoxaparin by minimizing the percentage of steady-state anti-Xa concentration (C(ss)) outside the therapeutic range of 0.5–1.2 IU ml(−1). METHODS: A nonlinear mixed effects model was developed with NONMEM® f...

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Hlavní autoři: Feng, Yan, Green, Bruce, Duffull, Stephen B, Kane-Gill, Sandra L, Bobek, Mary B, Bies, Robert R
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2006
Témata:
Pharmacodynamics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885085/
https://ncbi.nlm.nih.gov/pubmed/16842391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2006.02650.x
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