Simvastatin does not influence the intestinal P-glycoprotein and MPR2, and the disposition of talinolol after chronic medication in healthy subjects genotyped for the ABCB1, ABCC2 and SLCO1B1 polymorphisms

AIMS: To evaluate whether simvastatin influences (i) the intestinal expression of P-glycoprotein (P-gp) and MRP2, and (ii) the disposition of the β(1)-selective blocker talinolol, a substrate of these transporter proteins. METHODS: The disposition of talinolol after intravenous (30 mg) and single or...

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Bibliografiske detaljer
Main Authors: Bernsdorf, Annika, Giessmann, Thomas, Modess, Christiane, Wegner, Danilo, Igelbrink, Stefanie, Hecker, Ute, Haenisch, Sierk, Cascorbi, Ingolf, Terhaag, Bernd, Siegmund, Werner
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2006
Fag:
Drug Interactions
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885036/
https://ncbi.nlm.nih.gov/pubmed/16542205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2006.02599.x
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